ABCG8

5DO76424167470ENSG00000143921ENSMUSG00000024254Q9H221Q9DBM0NM_022437NM_001357321NM_001286005NM_026180NM_001347418NP_071882NP_001344250NP_001272934NP_001334347NP_080456ATP-binding cassette sub-family G member 8 is a protein that in humans is encoded by the ABCG8 gene. ATP-binding cassette sub-family G member 8 is a protein that in humans is encoded by the ABCG8 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. Click on genes, proteins and metabolites below to link to respective articles. This article incorporates text from the United States National Library of Medicine, which is in the public domain.