Monoblasts are bipotent cells that differentiated from hematopoietic stem cells. They are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.Blood cell lineageHematopoiesis Monoblasts are bipotent cells that differentiated from hematopoietic stem cells. They are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.