Nexin is a proteinous inter-doublet linkage that prevents microtubules in the outer layer of axonemes from moving with respect to one another, otherwise vesicular transport proteins such as dynein would dissolve the whole structure. Nexin is a proteinous inter-doublet linkage that prevents microtubules in the outer layer of axonemes from moving with respect to one another, otherwise vesicular transport proteins such as dynein would dissolve the whole structure.