Thrombospondin-2

1YO8, 2RHP705821826ENSG00000186340ENSMUSG00000023885P35442Q03350NM_003247NM_011581NP_003238NP_035711Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.1yo8: Strucuture of the C-terminal domain of human thrombospondin-2 Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. THBS2 has been shown to interact with MMP2.