Liver disease (also called hepatic disease) is a type of damage to or disease of the liver. Whenever the course of the problem lasts long, chronic liver disease ensues. Liver disease (also called hepatic disease) is a type of damage to or disease of the liver. Whenever the course of the problem lasts long, chronic liver disease ensues. Some of the signs and symptoms of liver disease are the following: There are more than a hundred different kinds of liver disease. These are some of the most common: