The standard enthalpy of reaction (denoted ΔHr⦵) is the enthalpy change that occurs in a system when matter is transformed by a given chemical reaction, when all reactants and products are in their standard states. The standard enthalpy of reaction (denoted ΔHr⦵) is the enthalpy change that occurs in a system when matter is transformed by a given chemical reaction, when all reactants and products are in their standard states.