PDE4B

1F0J, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ, 4NW7, 4WZI, 4X0F514218578ENSG00000184588ENSMUSG00000028525Q07343n/aNM_001297442NM_002600NM_001177980NM_001177981NM_001177982NM_001177983NM_019840NP_001284371NP_002591NP_001032418.1NP_002591.2n/acAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene.1f0j: CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B1ro6: Crystal structure of PDE4B2B complexed with Rolipram (R & S)1ro9: CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP1ror: CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP1tb5: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP1xlx: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast1xlz: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast1xm4: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast1xm6: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram1xmu: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast1xmy: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram1xn0: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram1xos: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil1xot: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil1y2h: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 1-(2-chloro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester1y2j: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Altered activity of this protein has been associated with schizophrenia and bipolar disorder. PDE4B is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram. PDE4B is involved in dopamine-associated and stress-related behaviours. It has also recently been found to modulate cognition, as reduction in PDE4B activity improves memory and long-term plasticity in mouse models, possibly supporting further therapeutic applications. AN2728, a boron-containing drug candidate that as of 2015 was under development by Anacor Pharmaceuticals for the topical treatment of psoriasis and atopic dermatitis (atopic eczema). mainly acting on PDE4B.