EIF1AX

1D7Q, 3ZJY, 4KZY, 4KZZ196413664ENSG00000173674ENSMUSG00000057561P47813Q60872NM_001412NM_010120NP_001403NP_034250Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene. This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.1d7q: HUMAN TRANSLATION INITIATION FACTOR EIF1A Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene. This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs. eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1. Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3. EIF1AX has been shown to interact with IPO13.