TRPV5

56302194352ENSG00000274348ENSG00000127412ENSMUSG00000036899Q9NQA5P69744NM_019841NM_001007572NP_062815NP_001007573Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene. Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene. TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequentual hyperparathyroidism, and bone loss. This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel, TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. TRPV5 has been shown to interact with S100A10. This article incorporates text from the United States National Library of Medicine, which is in the public domain.