ADD1

11811518ENSG00000087274ENSMUSG00000029106P35611Q9QYC0NM_001354754NM_001354755NM_001354756NM_001354757NM_001354759NM_001354761NM_001354762NM_001354758NM_001331082NM_001331083NM_001331084NM_001331085NM_001331086NM_001331087NP_001341683NP_001341684NP_001341685NP_001341686NP_001341688NP_001341690NP_001341691NP_001341687NP_001318012NP_001318013NP_001318014NP_001318015NP_001318016NP_038485Alpha-adducin is a protein that in humans is encoded by the ADD1 gene. Alpha-adducin is a protein that in humans is encoded by the ADD1 gene. Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.