HARS

1X59, 2LW7, 4G84, 4G85, 4PHC, 4X5O303515115ENSG00000170445ENSMUSG00000001380P12081Q61035NM_001289093NM_001289094NM_008214NP_001276023NP_002100NP_032240Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.1x59: Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. HARS has been shown to interact with EEF1B2 and EEF1G.