Central melanocortin system

The central melanocortin system is defined anatomically as a collection of central nervous system circuits which include: The central melanocortin system is defined anatomically as a collection of central nervous system circuits which include: This system is involved in body weight regulation through its role in appetite and energy expenditure via Leptin, Ghrelin and Agouti-related protein. It receives inputs from hormones, nutrients and afferent neural inputs, and is unique in its composition of fibers which express both agonists and antagonists of melanocortin receptors.