DGUOK

2OCP171627369ENSG00000114956ENSMUSG00000014554Q16854Q9QX60NM_001318859NM_001318860NM_001318861NM_001318862NM_001318863NM_001162521NM_013764NP_550438NP_550440NP_001155993NP_038792Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene.2ocp: Crystal Structure of Human Deoxyguanosine Kinase Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.