Sterol regulatory element-binding protein 2

1UKL672120788ENSG00000198911ENSMUSG00000022463Q12772Q3U1N2NM_004599NM_033218NP_004590NP_150087Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.1ukl: Crystal structure of Importin-beta and SREBP-2 complex Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene. This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain.Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis. SREBF2 has been shown to interact with INSIG1 and CREB-binding protein. This article incorporates text from the United States National Library of Medicine, which is in the public domain.