Caspase 7

1F1J, 1GQF, 1I4O, 1I51, 1K86, 1K88, 1KMC, 1SHJ, 1SHL, 2QL5, 2QL7, 2QL9, 2QLB, 2QLF, 2QLJ, 3EDR, 3H1P, 3IBC, 3IBF, 3R5K, 4FDL, 4FEA, 4HQ0, 4HQR, 4JB8, 4JJ8, 4JR1, 4JR2, 4LSZ, 4ZVR, 4ZVQ, 4ZVO, 4ZVU, 4ZVT, 4ZVS, 4ZVP, 5IC684012369ENSG00000165806ENSMUSG00000025076P55210P97864NM_033339NM_033340NM_001320911NM_007611NP_203124NP_203125NP_203126NP_031637Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene.CASP7 orthologs have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.1f1j: CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO1gqf: CRYSTAL STRUCTURE OF HUMAN PROCASPASE-71i4o: CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX1i51: CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP1k86: Crystal structure of caspase-71k88: Crystal structure of procaspase-71kmc: Crystal Structure of the Caspase-7 / XIAP-BIR2 Complex1shj: Caspase-7 in complex with DICA allosteric inhibitor1shl: CASPASE-7 IN COMPLEX WITH FICA ALLOSTERIC INHIBITOR Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene.CASP7 orthologs have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. Caspase 7 has been shown to interact with: