FABP7

1FDQ, 1FE3, 1JJX217312140ENSG00000164434ENSMUSG00000019874O15540P51880NM_001446NM_001319039NM_001319041NM_001319042NM_021272NP_001305968NP_001305970NP_001305971NP_001437NP_067247Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.1fdq: CRYSTAL STRUCTURE OF HUMAN BRAIN FATTY ACID BINDING PROTEIN1fe3: CRYSTAL STRUCTURE OF HUMAN BRAIN FATTY ACID BINDING PROTEIN OLEIC ACID1jjx: Solution Structure of Recombinant Human Brain-type Fatty acid Binding Protein Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene. The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. FABP7 is expressed, during development, in radial glia by the activation of Notch receptors. Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation. According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs. FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis. As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia, with one, that tested for only one SNP, showing negative and another, with seven SNPs, a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.