Grancalcin

1F4O, 1F4Q, 1K94, 1K9525801227960ENSG00000115271ENSMUSG00000026893P28676Q8VC88NM_001330270NM_001330271NM_145523NP_001317200NP_036330NP_663498Grancalcin is a protein that in humans is encoded by the GCA gene.1f4o: CRYSTAL STRUCTURE OF GRANCALCIN WITH BOUND CALCIUM1f4q: CRYSTAL STRUCTURE OF APO GRANCALCIN1k94: Crystal structure of des(1-52)grancalcin with bound calcium1k95: Crystal structure of des(1-52)grancalcin with bound calcium Grancalcin is a protein that in humans is encoded by the GCA gene. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. GCA (gene) has been shown to interact with SRI.