LRG1

11684476905ENSG00000171236ENSMUSG00000037095P02750Q91XL1NM_052972NM_029796NP_443204NP_084072Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1. Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1. The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation. LRG1 has been shown to be involved in promoting neovascularization (new blood vessel growth) through causing a switch in transforming growth factor beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway. Levels of the LRG protein are markedly elevated in acute appendicitis and therefore could be used as a diagnostic aid. LRG1 may be a potential therapeutic target for the treatment of diseases where there is aberrant neovascularization. This article incorporates text from the United States National Library of Medicine, which is in the public domain.