NCK2

1U5S, 1WX6, 1Z3K, 2B86, 2CIA, 2FRW, 2FRY, 2JXB, 4E6R844017974ENSG00000071051ENSMUSG00000066877O43639O55033NM_001004720NM_001004722NM_003581NM_010879NP_001004720NP_001004722NP_003572NP_035009Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene.1u5s: NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain1wx6: Solution structure of the SH3 domain of the human cytoplasmic protein NCK21z3k: Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain2b86: Solution structure of the first Src homology 3 domain of Nck22cia: HUMAN NCK2 SH2-DOMAIN IN COMPLEX WITH A DECAPHOSPHOPEPTIDE FROM TRANSLOCATED INTIMIN RECEPTOR (TIR) OF EPEC2frw: Solution structure of the second SH3 domain of human adaptor protein NCK22fry: Solution structure of the third SH3 domain of human NCK2 adaptor protein Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene. NCK belongs to family of adaptor proteins,There are two mammalian NCK genes, NCK1 and NCK2. NCK1 is located in chromosome 3 and NCK2 is located in chromosome 2. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCK2 has been shown to interact with: