A marker chromosome (mar) is a small fragment of a chromosome which generally cannot be identified without specialized genomic analysis due to the size of the fragment. The significance of a marker is variable as it depends on what material is contained within the marker. A marker chromosome (mar) is a small fragment of a chromosome which generally cannot be identified without specialized genomic analysis due to the size of the fragment. The significance of a marker is variable as it depends on what material is contained within the marker. Marker chromosomes occur sporadically about 70% of the time, with the remainder being inherited from a parent. About 50% of cases involve mosaicism, which affects severity of the condition. The frequency is approximately 3-4 per 10,000 people, and 1 in 300 people with mental retardation. Marker chromosomes typically occur in addition to the standard 46 chromosomes, making it a partial trisomy or supernumerary chromosome. A marker can be composed of inactive genetic material and have little or no effect, or it can carry active genes and cause genetic conditions such as iso(12p), which is associated with Pallister-Killian syndrome, and iso(18p), which is associated with mental retardation and syndromic facies. Chromosome 15 has been observed to contribute to a high number of marker chromosomes, but the reason has not been determined.