IRGM

34561154396ENSG00000237693ENSMUSG00000069874A1A4Y4n/aNM_001145805NM_001346557NM_019440NP_001139277NP_001333486n/aImmunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene. Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene. IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. This article incorporates text from the United States National Library of Medicine, which is in the public domain.