Hydrocortisone aceponate is a corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions). It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid. Hydrocortisone aceponate is a corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions). It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid.