SCN1B

632420266ENSG00000105711ENSMUSG00000019194Q07699P97952NM_001037NM_199037NM_001321605NM_011322NP_001028NP_001308534NP_950238NP_035452Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics. Mutation in the SCN1B gene are associated with disorders such as Brugada syndrome and GEFS. This article incorporates text from the United States National Library of Medicine, which is in the public domain.