Chronic allograft nephropathy

Chronic allograft nephropathy (CAN) is the leading cause of kidney transplant failure and happens month to years after the transplant. Chronic allograft nephropathy (CAN) is the leading cause of kidney transplant failure and happens month to years after the transplant. CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria. CAN is diagnosed by examination of tissue, e.g. a kidney biopsy. The histopathology is characterized by interstitial fibrosis, tubular atrophy,fibrotic intimal thickening of arteries and glomerulosclerosis.