Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) is an enzyme. This enzyme catalyses the following chemical reaction Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) is an enzyme. This enzyme catalyses the following chemical reaction Specific to (1-2') linkage of ribose-ribose bond of poly(ADP-ribose).