ACVR2A

3Q4T, 3SOC, 4ASX9211480ENSG00000121989ENSMUSG00000052155P27037P27038NM_001278579NM_001278580NM_001616NM_007396NP_001265508NP_001265509NP_001607NP_031422Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene.ACVR2A is an activin type 2 receptor.1bte: CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR1lx5: Crystal Structure of the BMP7/ActRII Extracellular Domain Complex2goo: Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene.ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2A has been shown to interact with: