Uremic pruritus

Uremic pruritus is caused by chronic kidney failure and is the most common internal systemic cause of itching.:52–3 Uremic pruritus is caused by chronic kidney failure and is the most common internal systemic cause of itching.:52–3 Nalfurafine, an orally-administered, centrally-acting κ-opioid receptor agonist, is approved to treat the condition in Japan.