Calpastatin

83112380ENSG00000153113ENSMUSG00000021585P20810P51125NM_001042445NM_001042446NM_001190442NM_001284212NM_001284213NM_001750NM_173060NM_173061NM_173062NM_173063NM_001330626NM_001330627NM_001330628NM_001330629NM_001330630NM_001330631NM_001330632NM_001330633NM_001330634NM_001301160NM_001301181NM_009817NP_001035910NP_001035911NP_001177371NP_001271141NP_001271142NP_001317555NP_001317556NP_001317557NP_001317558NP_001317559NP_001317560NP_001317561NP_001317562NP_001317563NP_001741NP_775083NP_001288089NP_001288110NP_033947Calpastatin is a protein that in humans is encoded by the CAST gene. Calpastatin is a protein that in humans is encoded by the CAST gene. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length natures of only some have been determined.