Diphthamide

Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2). Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2). Diphthamide is proposed to be a 2- Diphthamide ensures translation fidelity. The presence or absence of diphthamide is known to affect NF-κB or death receptor pathways. Diphthamide is biosynthesized from histidine and S-adenosyl methionine.