5-HT4 receptor

336015562ENSG00000164270ENSMUSG00000026322Q13639P97288NM_001286410NM_199453NM_008313NM_001364956NM_001364957NM_001364958NM_001364959NP_955525NP_032339NP_001351885NP_001351886NP_001351887NP_0013518885-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. 5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. This gene is a member of the family of human serotonin receptors, which are G protein-coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined. The receptor is located in the alimentary tract, urinary bladder, heart and adrenal gland as well as the central nervous system (CNS).In the CNS the receptor appears in the putamen, caudate nucleus, nucleus accumbens, globus pallidus, and substantia nigra, and to a lesser extent in the neocortex, raphe, pontine nuclei, and some areas of the thalamus.It has not been found in the cerebellum. Internalization is isoform-specific. Several drugs that act as 5-HT4 selective agonists have recently been introduced into use in both scientific research and clinical medicine. Some drugs that act as 5-HT4 agonists are also active as 5-HT3 antagonists, such as mosapride, metoclopramide, renzapride, and zacopride, and so these compounds cannot be considered highly selective. Research in this area is ongoing. SB-207,145 radiolabeled with carbon-11 is used as a radioligand for 5-HT4 in positron emission tomography pigand humanstudies. This article incorporates text from the United States National Library of Medicine, which is in the public domain.