CLK1

1Z57, 2VAG, 5J1V, 5J1W119512747ENSG00000013441ENSMUSG00000026034P49759P22518NM_001024646NM_001162407NM_004071NM_001042634NM_009905NP_001155879NP_004062NP_001036099Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.1z57: Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene. This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. CLK1 has been shown to interact with ASF/SF2.