DPA-713

DPA-713 or N,N-diethyl-2-(4-methoxyphenyl)-5,7-dimethylpyrazolopyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO). DPA-713 or N,N-diethyl-2-(4-methoxyphenyl)-5,7-dimethylpyrazolopyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO). The binding affinity of DPA-713 for TSPO is reported as Ki = 4.7 ± 0.2 nM. DPA-713 has been radiolabelled with carbon-11 as a potential radiotracer for imaging the TSPO using positron emission tomography (PET). Radiation dosimetry and biodistribution of DPA-713 have been assessed in healthy volunteers, indicating that DPA-713 is a suitable radioatracer for imaging the TSPO in humans.