Granulysin

Granulysin, also known as GNLY, is a protein which in humans is encoded by the GNLY gene. It is also known as NK-lysin (NKL) after NK cells; the cattle ortholog is sometimes referred to as Bo-lysin.1L9L10578n/aENSG00000115523n/aP22749n/aNM_001302758NM_006433NM_012483n/aNP_001289687NP_006424NP_036615n/aGranulysin is a protein present in cytolytic granules of cytotoxic T cells (CD8+) and natural killer cells along with perforin and granzymes. Granulysin is a member of the saposin-like protein (SAPLIP) family and is released from cytotoxic T cells upon antigen stimulation. Granulysin has antimicrobial activity against M. tuberculosis and other organisms. Granulysin is alternatively spliced, resulting in the NKG5 and 519 transcripts.GNLY orthologs have been identified in multiple species, including pigs, chicken, and cattle. Cattle has multiple copies of the gene with functional diversification.