S100A8

1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV627920201ENSG00000143546ENSMUSG00000056054P05109P27005NM_002964NM_001319196NM_001319197NM_001319198NM_001319201NM_013650NP_001306125NP_001306126NP_001306127NP_001306130NP_002955NP_038678S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as calgranulin A.1mr8: MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8 FROM HUMAN1xk4: Crystal structure of human calprotectin(S100A8/S100A9) S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.