477418027ENSG00000162599ENSMUSG00000028565Q12857Q02780NM_001134673NM_001145511NM_001145512NM_005595NM_001122952NM_001122953NM_010905NP_001128145NP_001138983NP_001138984NP_005586NP_001116424NP_001116425NP_035035Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene. Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene. Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization. This article incorporates text from the United States National Library of Medicine, which is in the public domain.