Bacterial cold water disease

Bacterial cold water disease (BCWD) is a bacterial disease of freshwater fish, specifically salmonid fish. It is caused by the bacterium Flavobacterium psychrophilum (previously classified in the genus Cytophaga), a psychrophilic, gram-negative rod-shaped bacterium of the family Flavobacteriaceae. This bacterium is found in fresh waters with the optimal growth temperature below 13⁰C, and it can be seen in any area with water temperatures consistently below 15⁰C. Salmon are the most commonly affected species. This disease is not zoonotic. Bacterial cold water disease (BCWD) is a bacterial disease of freshwater fish, specifically salmonid fish. It is caused by the bacterium Flavobacterium psychrophilum (previously classified in the genus Cytophaga), a psychrophilic, gram-negative rod-shaped bacterium of the family Flavobacteriaceae. This bacterium is found in fresh waters with the optimal growth temperature below 13⁰C, and it can be seen in any area with water temperatures consistently below 15⁰C. Salmon are the most commonly affected species. This disease is not zoonotic. Asymptomatic carrier fish and contaminated water provide reservoirs for disease. Transmission is mainly via horizontal gene transfer, but vertical transmission can also occur. BCWD may be referred to by a number of other names including cold water disease, peduncle disease, fit rot, tail rot and rainbow trout fry mortality syndrome. Fish infected with the pathogen Flavobacterium psychrophilum suffer from tissue erosion, jaw ulcerations, inflammation, and behavioral issues. Fins may appear dark, torn, split, ragged, frayed and may even be lost completely. Symptoms begin with tissue erosion, especially on the caudal fin. Other symptoms include the skin of the jaw “ulcerations”, pale in color gills, increased mucus production, blindness, inflammation of the gastrointestinal system, and behavioral issues such as “spiral swimming”. Affected fish are often lethargic and stop feeding. Infection may spread systemically. Salmonid fish can also get a chronic form of BCWD following recovery from typical BCWD. It is characterized by erratic “corkscrew” swimming, blackened tails and spinal deformities. In rainbow trout fry syndrome, acute disease with high mortality rates occurs. Infected fish may show signs of lethargy, inappetence and exopthalmos before death. A presumptive diagnosis can be made based on the history, clinical signs, pattern of mortality and water temperature, especially if there is a history of the disease in the area. The organism can be cultured for definitive diagnosis. Alternatively, histology should show periostitis, osteitis, meningitis and ganglioneuritis. This bacterium was first reported in 1922 at the Fisheries Biological station in Fairport Iowa and it has undergone many taxonomic revisions since then. The primary site of transmission is via fish to fish contact, particularly within the gills and the fins. Flavobacterium psychrophilum is a bacterium that reproduces and multiples via horizontal gene transfer. Although horizontal gene transfer is the most common way for bacterial growth to occur, there is evidence that vertical gene transfer may also play a role in transmission. Quaternary ammonium compounds can be added to the water of infected adult fish and fry. Alternatively, the antibiotic oxytetracycline can be given to adults, fry and broodstock.