TASP1

2A8I, 2A8J, 2A8L, 2A8M5561775812ENSG00000089123ENSMUSG00000039033Q9H6P5Q8R1G1NM_017714NM_001323602NM_001323603NM_001323604NM_001159640NM_001159641NM_001289611NM_175225NP_001310531NP_001310532NP_001310533NP_060184NP_001153112NP_001153113NP_001276540NP_780434Threonine aspartase 1 is an enzyme that in humans is encoded by the TASP1 gene.2a8i: Crystal Structure of human Taspase12a8j: Crystal Structure of human Taspase1 (acivated form)2a8l: Crystal structure of Human Taspase1 (T234A mutant)2a8m: Crystal Structure of Human Taspase1 (T234S mutant) Threonine aspartase 1 is an enzyme that in humans is encoded by the TASP1 gene. This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Cleavage of TFIIA has been found to drive spermatogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. Taspase1 is overexpressed in primary human cancers and functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Therefore, Taspase1 may serve as a novel anti-cancer therapeutic target.