In the development of vertebrate animals, the prechordal plate is a 'uniquely thickened portion' of the endoderm that is in contact with ectoderm immediately rostral to the cephalic tip of the notochord. It is the most likely origin of the rostral cranial mesoderm. In the development of vertebrate animals, the prechordal plate is a 'uniquely thickened portion' of the endoderm that is in contact with ectoderm immediately rostral to the cephalic tip of the notochord. It is the most likely origin of the rostral cranial mesoderm.