Amalgam tattoo is a grey, blue or black area of discoloration on the mucous membranes of the mouth, typically on the gums of the lower jaw. It is a healthcare caused lesion, is due to entry of dental amalgam into the soft tissues. It is common, painless, and benign, but it can be mistaken for melanoma. Amalgam tattoo is a grey, blue or black area of discoloration on the mucous membranes of the mouth, typically on the gums of the lower jaw. It is a healthcare caused lesion, is due to entry of dental amalgam into the soft tissues. It is common, painless, and benign, but it can be mistaken for melanoma. Amalgam tattoo usually occurs on the mandibular gingiva, often in an area in which a apicoectomy ('root-end filling') with amalgam was carried out.:138 After the gingiva, the alveolar mucosa and the buccal mucosa are the next most common sites, although any mucosal site in the mouth is possible. It is painless, and appears as a blue-black or grey discolored macule on the surface of the mucosa.:138:330:183 The borders of the tattoo are variable, and may be well defined, irregular or diffuse. Amalgam tattoo is caused by implantation of amalgam into the tissues.:183 It may occur in several ways: Over time, the amalgam particles embedded in the soft tissues corrode.:183 Macrophages take up the exogenous particles, and the silver in amalgam leads to staining of collagen fibers.:183 A similar appearance can be caused by implantation of graphite (e.g. from pencil leads), and is sometimes termed a graphite tattoo, although this is less common than tattooing with amalgam.:138 The diagnosis is clinical.:138 Amalgam tattoo can be distinguished from other causes of localized oral pigmentation because it does not change significantly in size or color,:138 although it may appear to slowly enlarge for several months after the initial implantation of the metal particles.:183 Some amalgam tattoos appear radio-opaque on radiographs (i.e. they show up on x-rays),:138 although in many cases amalgam tattoos have no radiographic features since the responsible particle(s) of amalgam are very small even though clinically the area of discolored mucosa is much larger. If necessary, the diagnosis can be confirmed histologically by excisional biopsy, which excludes nevi and melanomas.:138 If a biopsy is taken, the histopathologic appearance is: Theoretically, routine use of a dental dam during dental procedures which involve amalgam should reduce the risk of amalgam tattoo. No treatment is required since the lesion is entirely benign. Some suggest that amalgam tattoos are best surgically excised so as to ensure the lesion does not represent a melanoma.:138 Others say that excision should only be carried out if there is any doubt over the diagnosis, and that amalgam tattoos are managed by simple reassurance about the nature of the lesion.:330 For example, if radio-opaque particles are demonstrated on the x-ray, biopsy is unnecessary.