DEFA3

1DFN, 1ZMH, 1ZMI, 1ZMK, 2PM4, 2PM51668n/aENSG00000239839ENSG00000284835n/aP59666n/aNM_005217n/aNP_005208n/aDefensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene. Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.1zmh: Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala)1zmk: Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group2pm4: Human alpha-defensin 1 (multiple Arg->Lys mutant)2pm5: Human alpha-defensin 1 derivative (HNP1)1dfn: CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION2pm1: Derivative of human alpha-defensin 1 (HNP1)1zmi: Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group ) Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene. Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides. Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. This article incorporates text from the United States National Library of Medicine, which is in the public domain.