Lamin B receptor

2DIG393098386ENSG00000143815ENSMUSG00000004880Q14739Q3U9G9NM_002296NM_194442NM_133815NP_002287NP_919424NP_598576Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene.2dig: Solusion structure of the Todor domain of human Lamin-B receptor Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene. The protein encoded by this gene belongs to the ERG4/ERG24 family. It localizes to the inner membrane of the nuclear envelope and anchors the lamina and the heterochromatin to the membrane. It may mediate the interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. There is evidence tying it to Greenberg dysplasia and Pelger-Huet anomaly. Lamin B receptor has been shown to interact with CBX3 and CBX5. LBR also interacts with long non-coding RNA XIST in mouse cells and potentially assist the spreading XIST across X chromosome.