FERMT2

2LGX, 2LKO, 2MSU, 4F7H10979218952ENSG00000073712ENSMUSG00000037712Q96AC1Q8CIB5NM_001134999NM_001135000NM_006832NM_146054NM_001360525NM_001360526NP_001128471NP_001128472NP_006823NP_666166NP_001347454NP_001347455Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene. Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene. Kindlin-2 is the first of the kindlin protein to be discovered in 1994. It was detected in a screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein. FERMT2 is a component of extracellular matrix structures in mammalian cells and is required for proper control of cell shape change. A major task of kindlins is to regulate the activation of integrins. FERMT2 has been shown to interact with FBLIM1.