Karyopherin alpha 2

1EFX, 1QGK, 1QGR, 3FEX, 3FEY, 3WPT, 4E4V, 4WV6383816647ENSG00000182481ENSMUSG00000018362P52292P52293NM_002266NM_001320611NM_010655NP_001307540NP_002257NP_034785Importin subunit alpha-2 is a protein that in humans is encoded by the KPNA2 gene.1ejl: MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX1ejy: MOUSE IMPORTIN ALPHA-NUCLEOPLASMIN NLS PEPTIDE COMPLEX1ial: IMPORTIN ALPHA, MOUSE1iq1: CRYSTAL STRUCTURE OF THE IMPORTIN-ALPHA(44-54)-IMPORTIN-ALPHA(70-529) COMPLEX1pjm: Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex1pjn: Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex1q1s: Mouse Importin alpha- phosphorylated SV40 CN peptide complex1q1t: Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex1qgk: STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA1y2a: Structure of mammalian importin bound to the non-classical PLSCR1-NLS2c1m: NUP50:IMPORTIN-ALPHA COMPLEX Importin subunit alpha-2 is a protein that in humans is encoded by the KPNA2 gene. The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import are members of the alpha importin family of karyopherins such as importin subunit alpha-2. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination Karyopherin alpha 2 has been shown to interact with: