FBXW8

26259231672ENSG00000174989ENSMUSG00000032867Q8N3Y1Q8BIA4NM_012174NM_153348NM_172721NP_036306NP_699179NP_766309F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene. F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene. This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.