PCP4

512118546ENSG00000183036ENSMUSG00000090223P48539P63054NM_006198NM_008791NP_006189NP_032817Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene. Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM). PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity. Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene. Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM). PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity. PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons. PCP4 accelerates both the association and dissociation of calcium (Ca2+) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).