PLCB2

2FJU, 2ZKM533018796ENSG00000137841ENSMUSG00000040061Q00722A3KGF7NM_001284297NM_001284298NM_001284299NM_004573NM_001290790NM_177568NP_001271226NP_001271227NP_001271228NP_004564NP_001277719NP_8082361-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.2fju: Activated Rac1 bound to its effector phospholipase C beta 2 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene. The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits. PLCB2 has been shown to interact with MAP2K3 and TRPM7.