Umbellulone

Umbellulone is a headache-inducing monoterpene ketone found in the leaves of the tree Umbellularia californica, sometimes known as the 'headache tree'. Umbellulone is a headache-inducing monoterpene ketone found in the leaves of the tree Umbellularia californica, sometimes known as the 'headache tree'. It is hypothesized to cause headaches by influencing the trigeminovascular system via TRPA1.