Aquaporin 1

4CSK, 1FQY, 1H6I, 1IH535811826ENSG00000240583ENSMUSG00000004655P29972Q6JSD8Q6JSD7Q02013NM_001329872NM_007472NP_001316801NP_932766NP_031498Aquaporin 1 is a protein that in humans is encoded by the AQP1 gene.1fqy: STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY1h6i: A REFINED STRUCTURE OF HUMAN AQUAPORIN 11ih5: CRYSTAL STRUCTURE OF AQUAPORIN-11j4n: Crystal Structure of the AQP1 water channel Aquaporin 1 is a protein that in humans is encoded by the AQP1 gene. AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs. It is not regulated by vasopressin (ADH). Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein also as a non-selective cation channel. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. This article incorporates text from the United States National Library of Medicine, which is in the public domain.