TOX3

TOX high mobility group box family member 3, also known as TOX3, is a human gene. TOX high mobility group box family member 3, also known as TOX3, is a human gene. The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure. Mutations in the TOX3 gene are associated with an increased risk of breast cancer.