UVRAG

740578610ENSG00000198382ENSMUSG00000035354Q9P2Y5Q8K245NM_003369NM_178635NP_003360NP_848750UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene. UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene. This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.